Neha Pincha

Oct 19, 2023 | biorxiv.org | Dyuti Saha |Ravi Kiran |Sujaya Thannimangalath |Neha Pincha

AbstractVasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes the onset of fibrosis and we observed that this phenomenon is recapitulated in the Snail transgenic mouse model of SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction and vascular leakage.