Nestlé Research

May 18, 2024 | academic.oup.com | Nestlé Research

Tryptophan (TRP) metabolites along the kynurenine (KYN) pathway (KP) have been found to influence muscle. Pro-inflammatory cytokines are known to stimulate the degradation of TRP down the KP. Given that both inflammation and KP metabolites have been connected with loss of muscle, we assessed the potential mediating role of KP metabolites on inflammation and muscle mass in older men.

Apr 14, 2023 | journals.biologists.com | Nestlé Research |Antonio A. Nunez |de la Fuente |Thomas Jefferson

Glucose sensing in pancreatic β-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for downstream effectors of glucose-dependent signal transduction in INS-1E insulinoma cells, we identified the outer mitochondrial membrane protein SLC25A46.

Apr 11, 2023 | frontiersin.org | Nestlé Research

Célina Chkroun1*, Inez Trouwborst2, Anna Cherta-Murillo2, Lauren Owen2, Christian Darimont2 and Andreas Rytz1 1Clinical Research Unit, Nestlé Research, Switzerland 2Metabolic Health Department, Nestlé Institute Health Sciences, Nestlé Research, Switzerland The final, formatted version of the article will be published soon.