Nicholas A. Magnus

Jan 19, 2024 | dx.doi.org | Jesus Adrian Gonzalez |Jesús González |James Muir |Nicholas A. Magnus |Natalie G. Franklin-Charlesworth

Acylation of 5-amino-1H-1,2,4-triazoles is selective for the nitrogen atom at the ring 1-position of the heterocycle to give 1-acyl-5-amino-1H-1,2,4-triazoles. Thermal rearrangement of 1-acyl-5-amino-1H-1,2,4-triazoles has required high temperatures and concentrated to neat conditions to produce 5-acylamino-1H-1,2,4-triazoles. The mechanism of this rearrangement was thought to be intramolecular and later proposed to be intermolecular based on concentration effects.