Nicholas D. Brownstone

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Articles

Comparing Devices to Assess Facial Pigmentary and Inflammatory Conditions

Sep 13, 2024 | dermatologytimes.com | Nicholas D. Brownstone

Many dermatological conditions are assessed with the naked eye, including dermatoses that prominently feature erythema or pigmentary alteration. Disturbances of pigmentation include skin diseases such as melasma and dermatoheliosis as well as postinflammatory hyperpigmentation from inflammatory skin diseases such as atopic dermatitis and acne. Hypopigmented conditions of the skin include pityriasis alba, vitiligo, and postinflammatory hypopigmentation from conditions such as seborrheic dermatitis.
Research Highlights the Importance of Screening Patients for Alcohol Use Disorder

May 16, 2024 | dermatologytimes.com | Nicholas D. Brownstone

Research overwhelmingly indicates a link between chronic skin conditions, including pigmentary disorders, and poor mental health, including negative self-identity, social stigmatization, anxiety, and clinical depression.1 For example, a systematic review of observational studies and clinical trials found that, in addition to depression and anxiety, patients with vitiligo experience psychosocial comorbidities that result in decreased quality of life (QOL), including stigmatization, adjustment...
Psoriasis Therapies in 2024 and Beyond

Jan 16, 2024 | dermatologytimes.com | Nicholas D. Brownstone

Decades ago, psoriasis was still primarily considered a problem with hyperproliferation of the epidermis. Given the antiquated understanding of this disease pathophysiology, traditional oral immunosuppressive agents were used for moderate to severe presentations. Recent research into the pathophysiology of psoriasis has highlighted the importance of the immune-mediated nature of this very common inflammatory skin disease.
Investigating Links Between Cancer and Psoriasis Management

Nov 22, 2023 | dermatologytimes.com | Nicholas D. Brownstone

Research within the past few decades has elucidated the immune-mediated nature of the psoriasis and the specific elevated levels of chemokines and cytokines that promote inflammation in this disease. Many different cell types are involved, including keratinocytes, natural killer T cells, dermal dendritic cells, and macrophages. Activated dermal dendritic cells secrete IL-12 and IL-23, and both of these cytokines are integral in the cellular cascade of psoriasis pathophysiology.
Response to a Letter to the Editor regarding “The Integrated 31-Gene Expression Profile (i31-GEP) Test for Cutaneous Melanoma Outperforms a Clinicopathologic-Only Nomogram at Identifying Patients who can Forego Sentinel Lymph Node Biopsy” | SKIN The Journ

Nov 13, 2023 | jofskin.org | Danny Zakria |Nicholas D. Brownstone |Darrell S. Rigel

Main Article Content Keywords melanoma, MIA, nomogram, sentinel lymph node biopsy, SLNB, survival, node positivity References 1. Zakria, D., Brownstone, N. & Rigel, D.
The ABCs of CBD: Cannabinoids in Dermatology and Skin Care

Oct 23, 2023 | cannabissciencetech.com | Nicholas D. Brownstone

Cannabinoids (CBDs) are gaining popularity in both the skin care industry and the dermatology drug market and are becoming increasingly available to physicians and consumers. Cannabis-based personal care products suddenly seem ubiquitous all over the market, where CBD is a featured ingredient in everything from moisturizers and lotions to makeup (1).
The ABCs of CBD: Cannabinoids in Dermatology and Skin Care

Oct 9, 2023 | drugtopics.com | Nicholas D. Brownstone

October 9, 2023Drug Topics JournalDrug Topics October 2023Cannabinoids (CBDs) are gaining popularity in both the skin care industry and the dermatology drug market and are becoming increasingly available to physicians and consumers.
The ABCs of CBD: Cannabinoids in Dermatology and Skin Care

Aug 23, 2023 | cannabisculture.com | Nicholas D. Brownstone

Cannabinoids (CBDs) are gaining popularity in both the skin care industry and the dermatology drug market and are becoming increasingly available to physicians and consumers. Cannabis-based personal care products suddenly seem ubiquitous all over the market, where CBD is a featured ingredient in everything from moisturizers and lotions to makeup.
The ABCs of CBD: Cannabinoids in Dermatology and Skin Care

Aug 23, 2023 | dermatologytimes.com | Nicholas D. Brownstone

Aug 23, 2023Dermatology TimesDermatology Times, August 2023 (Vol. 44. No. 08)Cannabis-based personal care products suddenly seem ubiquitous all over the market, where CBD is a featured ingredient in everything from moisturizers and lotions to makeup. Cannabinoids (CBDs) are gaining popularity in both the skin care industry and the dermatology drug market and are becoming increasingly available to physicians and consumers.
Integrating Precision Medicine into Medical Dermatology Clinical Practice: An Expert Consensus Panel.

Jun 19, 2023 | physiciansweekly.com | Danny Zakria |Nicholas D. Brownstone |April Armstrong |Erin Boh

Precision medicine utilizes an individual’s genomics to improve diagnosis, prognosis, and therapy. The joint American Academy of Dermatology and National Psoriasis Foundation 2019 guidelines recognized the need to identify biomarkers that can predict the optimal biologic agent for an individual patient. This paper examines the current state of precision medicine in dermatology and how its use can improve outcomes in psoriasis.