Nicholas R Leclerc

2 months ago | biorxiv.org | Nicholas R Leclerc |Toby F. Dunne |Sudati Shrestha |Cory Johnson

AbstractTarget of Rapamycin (TOR) complexes and G-protein-coupled receptors (GPCRs) are crucial signaling hubs that coordinate adaptive responses to environmental inputs. While GPCR-mediated regulation of TOR has been extensively studied, little is known about TOR-mediated regulation of GPCRs. Here, we establish TOR as a regulator of GPCR signaling via its control of receptor endocytosis in the yeast mating system.