Nickilou Y. Krigbaum

May 16, 2024 | digitalcommons.library.tmc.edu | Caitlin Murphy |Piera M. Cirillo |Nickilou Y. Krigbaum |Amit Singal

BACKGROUND: Incidence rates of colorectal cancer (CRC) are increasing among adults born in and after the 1960s, implicating pregnancy-related exposures introduced at that time as risk factors. Dicyclomine, an antispasmodic used to treat irritable bowel syndrome, was initially included in Bendectin (comprising doxylamine, pyridoxine, and dicyclomine), an antiemetic prescribed during pregnancy in the 1960s.

May 16, 2024 | digitalcommons.library.tmc.edu | Caitlin Murphy |Piera M. Cirillo |Nickilou Y. Krigbaum |Amit Singal

BACKGROUND: Incidence rates of colorectal cancer (CRC) are increasing among younger adults and in mid-life, implicating exposures in early life as risk factors. We examined the association between in-utero exposure to antibiotics and risk of CRC in adult offspring. METHODS: The Child Health and Development Studies is a prospective cohort of women receiving prenatal care between 1959 and 1966 in Oakland, California, with deliveries through June 1967.