Nicola M. Karakatsanis

Jan 16, 2024 | cell.com | Joshua J. Hamey |Marc Wilkins |Nicola M. Karakatsanis

Highlights Human histone demethylases are extensively phosphorylated, which can influence when and where they act on chromatin. Phosphorylation influences the function of histone demethylases via distinct mechanisms. Phosphorylation of histone demethylases occurs primarily in intrinsically disordered regions and at the interface of histone demethylase protein–protein interactions.