Nicola Whiffin

Jul 15, 2024 | nature.com | Nicola Whiffin

Genetic constraint identifies genes under selection against loss-of-function, but existing methods are inaccurate for shorter genes. A new study overcomes this key limitation to ascribe more confident predictions to all human protein-coding genes.

Apr 12, 2023 | cell.com | Julie L Aspden |Edward Wallace |Nicola Whiffin

SummaryExons are regions of DNA that are transcribed to RNA and retained after introns are spliced out. However, the term “exon” is often misused as synonymous to “protein coding,” including in some literature and textbook definitions. In contrast, only a fraction of exonic sequences are protein coding (<30% in humans).