Nicolas Timpson

May 13, 2024 | nature.com | Alexander J. Mentzer |Martin Pollard |Deepti Gurdasani |Amanda Chong |Rasmus Nielsen |Nicolas Timpson | +10 more

AbstractHow human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South Africa (n = 755), identifying associations between human leukocyte antigen (HLA) and antibody response for five of eight tested antigens spanning pertussis, diphtheria and hepatitis B vaccines.