Articles
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Sep 1, 2023 |
biorxiv.org | Mariusz Karbowski |Nicolas Verhoeven |Yumiko Oshima |Etienne Cartier-Zamorano
AbstractPeroxisome de novo biogenesis requires yet unidentified mitochondrial proteins. We report that the outer mitochondrial membrane (OMM)-associated E3 Ub ligase MARCH5 is vital for generating mitochondria-derived pre-peroxisomes. MARCH5 knockout results in accumulation of immature peroxisomes and lower expression of various peroxisomal proteins.
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