Nikita Sushentsev

Jul 16, 2024 | nature.com | Nikita Sushentsev |Daniel Birtles |Stephanie Ling |Mary A McLean |Jodi Miller |Ian Mills | +2 more

AbstractHyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechanisms underpinning differential [1-13C]lactate labelling between benign and malignant prostate, as well as in tumours containing cribriform and non-cribriform Gleason pattern 4 disease.