Ningzheng Dong

Jan 19, 2025 | nature.com | Ningzheng Dong

AbstractPositively charged residues are commonly located near the cytoplasm-membrane interface, which is known as the positive-inside rule in membrane topology. The mechanism underlying the function of these charged residues remains poorly understood. Herein, we studied the function of cytoplasmic residues in corin, a type II transmembrane serine protease in cardiovascular biology.

Oct 22, 2024 | nature.com | Zibin Zhou |Ningzheng Dong |Qingyu Wu

AbstractCorin is a protease that activates atrial natriuretic peptide (ANP), a hormone in cardiovascular homeostasis. Structurally, ANP is similar to C-type natriuretic peptide (CNP) crucial in bone development. Here, we examine the role of corin and ANP in chondrocyte differentiation and bone formation. We show that in Corin and Nppa (encoding ANP) knockout (KO) mice, chondrocyte differentiation is impaired, resulting in shortened limb long bones.

Jun 23, 2023 | mdpi.com | Qingyu Wu |Shuo Li |Xianrui Zhang |Ningzheng Dong

Open AccessReview by Qingyu Wu 1,*, Shuo Li 2, Xianrui Zhang 1 and Ningzheng Dong 1,3 1 Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China 2 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA 3 NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, Soochow University, Suzhou 215006, China *...