Niran Hadad

Jan 9, 2024 | biorxiv.org | Michael Saul |Elizabeth Litkowski |Niran Hadad |Amy Dunn

AbstractAlzheimer's disease (AD) is a prevalent and costly age-related dementia. Heritable factors account for 58-79% of variation in late-onset AD, but substantial variation remains in age-of-onset, disease severity, and whether those with high-risk genotypes acquire AD. To emulate the diversity seen in human populations, we utilized the AD-BXD mouse panel. This genetically diverse resource combines AD genotypes with multiple BXD strains to discover new genetic drivers of AD resilience.