Nneka E. Mbah

Sep 30, 2024 | digitalcommons.library.tmc.edu | Nneka E. Mbah |Mengrou Shan |Kristen Loesel |Lin Lin

AbstractT cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (TH17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy.