Noah Stansfield

5 days ago | cgtlive.com | Jamie M. Jacobs |Noah Stansfield

“I think what's really notable about these findings is not just what significant and clinically meaningful improvements we saw in quality of life and some of our other secondary outcomes, but also how engaged caregivers were using this app content.”For patients receiving many cell-based and other advanced therapies, including hematopoietic stem cell transplant (HSCT), the role of the caregiver is of great importance.

1 week ago | cgtlive.com | Noah Stansfield

Welcome to CGTLive®’s Weekly Rewind! We’ve compiled 5 highlights from this week’s coverage of advances in gene and cell therapies, including FDA actions, notable research, and interviews with experts across the field. The patient’s death occurred after an acute systemic infection and was associated with an unexpected SAE of clinical complications related to a capillary leak syndrome.

1 week ago | cgtlive.com | Joseph A Fraietta |Janna C. Minehart |Caroline DiOrio |Noah Stansfield

0:00 – Intro and guest introduction 2:00 – Challenges in predicting toxicities in preclinical models 10:00 – How manufacturing parameter changes can affect toxicity rates 13:06 – Strategies for managing inflammatory toxicities in smaller medical centers 19:52 – Goal of decoupling treatment potency from toxicity 20:44 – Potential for future unknown toxicities in immunotherapies 24:52 – Challenges in defining and identifying immune effector cell-associated HLH-like syndrome (IEC-HS) biomarkers...

1 week ago | cgtlive.com | Noah Stansfield

According to the ALS Association, a person is diagnosed with amyotrophic lateral sclerosis (ALS), which constitutes a progressive neurodegenerative disease affecting brain and spinal cord nerve cells, every 90 minutes. Diagnosis with ALS can take a substantial period of time—months or years—and although about 10% of patients can have their condition linked to an inherited mutated gene, 90% of cases are not known to be related to any genetic cause or family history.

1 week ago | cgtlive.com | Noah Stansfield

The cell and gene therapy sectors are growing exponentially, with new players emerging daily and much progress being made both in and out of the lab. CGTLive®’s Around the Helix is your chance to catch up with the latest news in cell and gene therapies, including partnerships, pipeline updates, and more. Have a cell and gene therapy news update you’d like to share with our editorial team?