Nordic EMBL Partnership

Oct 22, 2024 | academic.oup.com | Nordic EMBL Partnership

Since high-throughput techniques became a staple in biological science laboratories, computational algorithms, and scientific software have boomed. However, the development of bioinformatics software usually lacks software development quality standards. The resulting software code is hard to test, reuse, and maintain.

Feb 19, 2024 | onlinelibrary.wiley.com | Nordic EMBL Partnership

The crystal structure of myco­thiol di­sulfide reductase (Mtr) provides mechanistic insight into the specific low-molecular-weight thiol reductase activity of Actinobacteria Javier Gutiérrez-Fernández,a,b* Hans-Petter Hersletha* and Marta Hammerstada* aSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo, PO Box 1066, Blindern, 0316 Oslo, Norway, and bCentre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway...

Oct 6, 2023 | academic.oup.com | Nordic EMBL Partnership |Camila Miranda |Ma Usa |Geir Kjetil

Gene co-expression measurements are widely used in computational biology to identify coordinated expression patterns across a group of samples. Coordinated expression of genes may indicate that they are controlled by the same transcriptional regulatory program, or involved in common biological processes. Gene co-expression is generally estimated from RNA-Sequencing data, which are commonly normalized to remove technical variability.

Jul 7, 2023 | genomemedicine.biomedcentral.com | Nordic EMBL Partnership

DataTo train MuAt models, we utilized WGS data from the Pan-Cancer Analysis of Whole Genome (PCAWG) project and WES data from the Pan-Cancer Atlas project of TCGA. PCAWG analysed whole genomes of 2658 human tumours and matched normal samples across 38 tumour types obtained from International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) donors [38].