not hurtBy

Mar 26, 2024 | science.org | Rui Wang |not hurtBy |Leslie K. Ferrarelli

AbstractBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Microglia are a double-edged sword in neurodegenerative diseases; thus, harnessing their therapeutic potential currently presents a catch-22.

Mar 26, 2024 | science.org | Rui Wang |Leslie K. Ferrarelli |Hongyang Sun |not hurtBy

Research Article NEUROINFLAMMATION Rui Wang https://orcid.org/0000-0001-8346-5783, Hongyang Sun https://orcid.org/0009-0005-4424-4386, [...] , Yifan Cao, Zhixiong Zhang, [...] , Yajing Chen https://orcid.org/0009-0003-6268-4815, Xiying Wang, Lele Liu https://orcid.org/0009-0004-4100-7388, Jin Wu https://orcid.org/0009-0006-5075-8313, Hao Xu, [...] , Dan Wu, Chenchen Mu, Zongbing Hao https://orcid.org/0000-0002-0059-9848, Song Qin https://orcid.org/0000-0002-5569-4324, Haigang Ren...

Mar 26, 2024 | sciencemag.org | Rui Wang |not hurtBy |Leslie K. Ferrarelli

Editors' ChoiceGLIAMicroglia are a double-edged sword in neurodegenerative diseases; thus, harnessing their therapeutic potential currently presents a catch-22. In rodent models of Alzheimer’s disease (AD), for example, activated microglia mediate the clearance of neurotoxic β-amyloid (Aβ) aggregates from the brain, but they also phagocytose synapses, contributing to neurodegeneration and functional impairments. Lv et al.

Mar 26, 2024 | sciencemag.org | Rui Wang |not hurtBy |Leslie K. Ferrarelli |Hongyang Sun

Published In Science SignalingVolume 17 | Issue 829March 2024Article versionsSubmission historyReceived: 12 September 2023Accepted: 6 March 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank X. Su at Soochow University for technical assistance with the measurement of GC species. We also thank Y. Shen at Soochow University for statistical expertise.