Oana M. Constantin

Jan 9, 2025 | nature.com | Xiaodong Duan |Chong Zhang |Yujie Wu |Jun Ju |Oana M. Constantin |Yifan Pan | +6 more

AbstractOptogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While transcranial photoexcitation of neurons has been achieved, noninvasive optogenetic inhibition for treating hyperexcitability-induced neurological disorders has remained elusive.