Ola Magne Vagnildhaug

Feb 11, 2024 | onlinelibrary.wiley.com | Trude Balstad |Christine Greil |Ola Magne Vagnildhaug |Inger Ottestad

Introduction Loss of appetite is a critical phenotypic feature of cancer cachexia and, combined with reduced dietary intake, drives weight loss.1 The underlying biology of this is complex and attributable to disturbances of homeostatic mechanisms involved in the regulation of energy balance.2 The hypothalamus is the key regulator of appetite and can be modulated by several factors including inflammatory cytokines, hormones, neurotransmitters, and sympathetic nerves and vagal afferent fibres.3...