Olan Jackson-Weaver

May 29, 2024 | biorxiv.org | Jiang Qian |Olan Jackson-Weaver |Yudao Shen |Jian Jin

AbstractCardiac fibrosis is a recognized cause of morbidity and mortality, yet effective pharmacological therapy that directly targets the fibrotic process remains lacking. Here we surveyed a group of methyltransferases known as protein arginine methyltransferases (PRMT) and demonstrated that PRMT1, which is the most highly expressed PRMT in the heart, was upregulated in activated cardiac fibroblasts, or myofibroblasts, in failing hearts.