Oleh Krupa

Feb 8, 2025 | biorxiv.org | Nana Matoba |Oleh Krupa |Jess Bell |Jessica C. McAffee

AbstractGenetic association studies have identified hundreds of largely non-coding loci associated with inter-individual differences in the structure of the human cortex, though the specific genetic variants that impact regulatory activity are unknown. We implemented a Massively Parallel Reporter Assay (MPRA) to measure the regulatory activity of 9,092 cortical structure associated DNA variants in human neural progenitor cells during Wnt stimulation and at baseline.

Aug 20, 2024 | cell.com | Nil Aygün |Celine K. Vuong |Oleh Krupa |Jessica Mory |brandon le |Jordan M Valone | +8 more

Keywords RNA editing alternative polyadenylation quantitative trait loci genome-wide association studies missing regulation neurogenesis Introduction Genome-wide association studies (GWASs) have detected many genetic loci associated with risk for neuropsychiatric disorders and inter-individual variation in brain structure and other brain-related traits.1,2,3,4,5,6 The vast majority of brain-relevant trait GWAS loci have been detected within non-coding genomic regions and do not change protein...