Olivier Dennler

Oct 13, 2024 | biorxiv.org | Olivier Dennler |Colm A. Ryan |College Dublin

AbstractGene duplication is the primary source of new genes, resulting in most genes having identifiable paralogs. Over evolutionary time scales, paralog pairs may diverge in some respects but many retain the ability to perform the same functional role. Protein sequence identity is often used as a proxy for functional similarity and can predict shared functions between paralogs as revealed by synthetic lethal experiments.