Olivier M. Vanakker

Jul 27, 2023 | frontiersin.org | De Luca |Di Chiara |Enrico Silvio |Olivier M. Vanakker

Introduction The TTN gene (OMIM 188840) is located on chromosome 2q31 and consists of 363 coding exons. Titin is the largest protein in nature and a major component of muscle sarcomere. Its structure is composed of 27,000–33,000 amino acids in length with an estimated molecular weight ranging from 2,900 to 3,800 kDa (1, 2).