Olivier Saulnier

Jul 18, 2024 | nature.com | Olivier Saulnier |Paul Jerard Layug |Kimberly A Aldinger |Christopher Porter |Stephane Richard |Brad Doble | +1 more

AbstractOTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 MB. Here we demonstrate a noncanonical role for OTX2 in group 3 MB alternative splicing. OTX2 associates with the large assembly of splicing regulators complex through protein–protein interactions and regulates a stem cell splicing program.