Olof Gidlöf

2 months ago | nature.com | Olof Gidlöf |Jakob Lundgren |Entela Bollano |Selvi Celik |Philipp Rentzsch |Molly Martorella | +14 more

AbstractThe genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients. Gene lists were compiled through a systematic literature review. Variants were prioritized for pathogenicity and classified manually.