Omar Abouyousef

May 21, 2024 | onlinelibrary.wiley.com | Philippe M Campeau |Yosra Mehrjoo |Abdullah Aldowaish |Omar Abouyousef

1 INTRODUCTION The essential CMG complex (CDC45-MCM-GINS) allows the unwinding of the DNA double helix and the initiation of DNA replication during the S phase of the cell cycle (reviewed in Reference 1). Pathogenic variants of this complex have previously been implicated in Meier–Gorlin syndrome (MGORS),2 an autosomal recessive disorder characterized by growth delay, microtia, and patellar hypo/aplasia.