Ottavia Delmonte

May 22, 2024 | sciencedirect.com | Ottavia Delmonte |Luigi D. Notarangelo

Section snippetsStudy populationPatients with CRSsNP and patients with CRSwNP who had ESS at Northwestern Memorial Hospital and consented to collection of surgical samples in our research repository between 2017 and 2021 were prospectively invited to participate in a research evaluation 6 to 12 months after ESS (Fig 1). The patients provided written informed consent to access nasal secretions and clinical information collected before and after ESS.

Jan 16, 2024 | onlinelibrary.wiley.com | Sarah S. Dinges |Luigi D. Notarangelo |Ottavia Delmonte |Kayla Amini

CONFLICT OF INTEREST STATEMENT The authors declare no competing interests. REFERENCES 1. The function of the thymus and its impact on modern medicine. Science. 2020; 369(6503):eaba2429. doi:10.1126/science.aba2429 2. ‘Nude’, a new hairless gene with pleiotropic effects in the mouse. Genet Res. 1966; 8(3): 295-309. doi:10.1017/s0016672300010168 3. Absence of thymus in a mouse mutant. Nature. 1968; 217(5126): 370-371. doi:10.1038/217370a0 4, . Congenital absence of the thymus.

Dec 2, 2023 | sciencedirect.com | Ottavia Delmonte |Luigi D. Notarangelo |Hazel Wilkie |Raif S. Geha

Section snippetsMethodsDetailed methods are presented in the Methods section in this article’s Online Repository (available at www.jacionline.org). Briefly, the imputed Immunochip data of patients with CVID (n = 299) and controls (n = 900) were selected from the database of Center for Applied Genomics, the Children’s Hospital of Philadelphia (CHOP) and were used to compute the linkage disequilibrium between SNPs at the CLEC16A intron 19 region for fine-mapping.