Pål Marius Bjørnstad

Feb 12, 2024 | nature.com | Asbjørn Holmgren |Ibrahim Akkouh |Kevin O’Connell |Jordi Requena Osete |Pål Marius Bjørnstad |Srdjan Djurovic

AbstractBipolar disorder is a severe neuro-psychiatric condition where genome-wide association and sequencing studies have pointed to dysregulated gene expression as likely to be causal. We observed strong correlation in expression between GWAS-associated genes and hypothesised that healthy function depends on balance in the relative expression levels of the associated genes and that patients display stoichiometric imbalance.