Parsa Akbari

Aug 18, 2023 | nature.com | Parsa Akbari |Luca Stefanucci |Kousik Kundu |Roman Kreuzhuber |Erik L. Bao |Janine Collins | +12 more

AbstractBlood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. We perform genome-wide association studies of 63 flow-cytometry derived cellular phenotypes—including cell-type specific measures of granularity, nucleic acid content and reactivity—in 41,515 participants in the INTERVAL study.