Pascal Duchesneau

Sep 7, 2024 | biorxiv.org | Andras Nagy |Li Guo |Pascal Duchesneau |Evan Sawula

AbstractHere, we present a combination of cell and gene therapy that harnesses the regenerative properties of GDF11 in age-related pulmonary fibrosis. Our genome-edited FailSafeTM-GDF11 mouse ESC line provides controlled proliferation and efficient derivation to lung progenitors while inducibly expressing GDF11. When these cells were transplanted into bleomycin-injured aged mice, they acted as a source of reparative cells, restoring the damaged alveolar epithelium.