Patricia D. Castro

Jan 6, 2025 | digitalcommons.library.tmc.edu | Chad J. Creighton |Flora Zhang |Yiqun Zhang |Patricia D. Castro

KeywordsMale, Humans, DNA Methylation, Transcriptome, Black or African American, Epigenomics, Prostatic Neoplasms, RNA, Messenger, Gene Expression Regulation, Neoplastic, CpG Islands, Carrier Proteins, Nerve Tissue Proteins, Clinically localized prostate cancer, DNA methylation, gene expression, Genome-wide profiling, CpG methylation, African American menAbstractAfrican American (AA) men have the highest incidence and mortality rate from Prostate cancer (PCa) than any other racial/ethnic group.

Mar 11, 2023 | nature.com | Fei Yuan |Patricia D. Castro |Chad J. Creighton |Michael M. Ittmann

AbstractThe regenerative potential of the endometrium is attributed to endometrial stem cells; however, the signaling pathways controlling its regenerative potential remain obscure. In this study, genetic mouse models and endometrial organoids are used to demonstrate that SMAD2/3 signaling controls endometrial regeneration and differentiation.