Patrick S. Dischinger

Nov 25, 2023 | biorxiv.org | Rachel House |Elizabeth A Tovar |Curt J Essenburg |Patrick S. Dischinger

AbstractObjective: NF1 is a tumor suppressor gene and its protein product, neurofibromin, is the key negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27% of breast cancers exhibit damaging NF1 alterations. NF1 loss–of–function is a frequent event in the genomic evolution of estrogen receptor (ER)+ breast cancer metastasis and endocrine resistance.