Patrick Wilson

Apr 17, 2023 | jci.org | Shiv Pillai |Yoshihiro Kawaoka |Patrick Wilson

AbstractThe continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a patient, that targets a vulnerable site on the spike protein receptor binding domain when it adopts a configuration called the “up” conformation.

Mar 23, 2023 | nature.com | Patrick Wilson

Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as ‘original antigenic sin’. Here, molecular fate-mapping defines an ‘addiction’ of boosted antibodies to primary clones, and OAS-like suppression of new clones, to a degree inversely related to boosting antigenic distance. Booster immunizations are a hallmark of most vaccination schedules, including against highly mutative viruses such as influenza and SARS-CoV-2.