Patroklos Samaras

Oct 30, 2023 | nature.com | Paul Brear |Larsen Vornholz |Stephanie Wilhelm |Patroklos Samaras |David Litchfield |Guillaume Médard | +4 more

AbstractMedicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical probes to study kinase biology. Because of polypharmacology, a large part of the human kinome currently lacks selective chemical probes. To discover such probes, we profiled 1,183 compounds from drug discovery projects in lysates of cancer cell lines using Kinobeads.