Paul A. Dalby

Oct 28, 2024 | allevents.in | Paul A. Dalby

Webinar to explore the impact Engineering has had on clinical and healthcare research at UCL and how to engage with Engineering researchers. About this EventEngineering in Healthcare ResearchWelcome to our online event where we explore the intersection of engineering and healthcare research! Join us on Fri Nov 08 2024 at 13:00 GMT as we showcase the impact of engineering research at UCL on healthcare.

Sep 30, 2024 | dx.doi.org | Yuhan Wang |Hywel Williams |Duygu Dikicioglu |Paul A. Dalby

IntroductionClick to copy section linkSection link copied!Measuring the physicochemical and biophysical properties of proteins, such as self-interaction and aggregation, thermal stability, and colloidal stability, is a critical route for evaluating the developability and formulation performance of antibody-based therapies prior to process development and real-time formulation testing.

Jan 13, 2024 | nature.com | Paul A. Dalby

AbstractImproving the range of substrates accepted by enzymes with high catalytic activity remains an important goal for the industrialisation of biocatalysis. Many enzymes catalyse two-substrate reactions which increases the complexity in engineering them for the synthesis of alternative products. Often mutations are found independently that can improve the acceptance of alternatives to each of the two substrates.

Jun 5, 2023 | nature.com | Cheng Zhang |Paul A. Dalby

AbstractDistribution of vaccines which require refrigerated or frozen storage can be challenging and expensive. The adenovirus vector platform has been widely used for COVID-19 vaccines while several further candidate vaccines using the platform are in clinical development. In current liquid formulations, adenoviruses require distribution at 2–8 °C. The development of formulations suitable for ambient temperature distribution would be advantageous.