Paul Albert

Oct 7, 2024 | onlinelibrary.wiley.com | Jin Yang |Wei Zhang |Paul Albert |Aiyi Liu

1 Introduction In biomedical and epidemiological studies, diagnostic biomarkers are often used to distinguish diseased individuals from healthy ones in a potentially fast and economical way. For biomarkers with continuous results, the receiver operating characteristic (ROC) curve is a standard statistical tool to evaluate and compare their accuracy, consider Hanley and McNeil [1], Wieand et al. [2], Zou and Hall [3], Yang, Lu, and Zhao [4], and Yin and Tian [5], among others.

Oct 7, 2024 | onlinelibrary.wiley.com | Jin Yang |Wei Zhang |Paul Albert |Aiyi Liu

1 Introduction In biomedical and epidemiological studies, diagnostic biomarkers are often used to distinguish diseased individuals from healthy ones in a potentially fast and economical way. For biomarkers with continuous results, the receiver operating characteristic (ROC) curve is a standard statistical tool to evaluate and compare their accuracy, consider Hanley and McNeil [1], Wieand et al. [2], Zou and Hall [3], Yang, Lu, and Zhao [4], and Yin and Tian [5], among others.

Jan 17, 2024 | jneurosci.org | Paul Albert

Citation Tools Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety–Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice Journal of Neuroscience 44 (3) e1147232023; DOI: 10.1523/JNEUROSCI.1147-23.2023 Citation Manager Formats Recaptcha requires verification.

Nov 28, 2023 | jneurosci.org | Paul Albert

AbstractSelective serotonin (5-HT) reuptake inhibitors (SSRIs) are only 30% effective for remission in subjects with major depression, and the best treatments for SSRI-resistant patients remain unclear. To model SSRI resistance, we used cF1ko mice with conditional deletion of the repressor Freud-1/CC2D1A in adult 5-HT neurons. Within weeks, this deletion leads to over-expression of 5-HT1A autoreceptors, reduced serotonergic activity and a fluoxetine-resistant anxiety-depression phenotype.

Feb 3, 2023 | vice.com | Paul Albert

PARIS, FRANCE - 19 JUIN : L'écrivain Michel Houellebecq et sa femme Qianyum Lysis Li. Fashion Week de Paris. (Photo par Bertrand Rindoff Petroff/Getty Images)Poète, romancier, acteur, essayiste, Michel Houellebecq, l'auteur français vivant le plus lu au monde, prix Goncourt et pressenti pour le Nobel de littérature, a plusieurs cordes à son arc d’artiste. Depuis quelques jours, il peut se targuer d’en avoir ajouté une nouvelle : star du porno.