Paul Solomon

Nov 20, 2023 | jbc.org | Byrareddy S.N |Jason Low |Natasha Jones |Paul Solomon

ABSTRACTBromodomains regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins, perhaps most prominently transcription factors. The likely transient nature and low stoichiometry of such modifications, however, has made it challenging to fully define the interactome of any given bromodomain.