Pedro Romero Charria

Oct 28, 2024 | biorxiv.org | Pedro Romero Charria |Cristina Navarrete |Vladimir Ovchinnikov |Luke A Sarre

AbstractDNA methylation in the form of 5-methylcytosine (5mC) is widespread in eukaryotes, while the presence of N6-methyladenine (6mA) has sparked considerable debate. Methodological disparities in quantifying and mapping 6mA in genomic DNA have fueled this controversy. Yet, the distantly related early branching fungi, ciliates and the algae Chlamydomonas reinhardtii exhibit robust 6mA methylation patterns, but the origin and evolution of 6mA remain unknown.