Pei-Pei Zhang

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Articles

A GluN2B disease-associated variant promotes degradation of NMDA receptors via autophagy

Jan 13, 2025 | biorxiv.org | Taylor M Benske |Marnie Williams |Pei-Pei Zhang |Adrian J Palumbo

AbstractN-methyl-D-aspartate receptors (NMDARs) are essential for excitatory neurotransmission and their pathogenic variants can lead to proteostasis defects and thus neurological diseases. However, how the proteostasis network degrades pathogenic variants is not well understood.

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