Peng-Jui Chen

Apr 24, 2024 | nature.com | Andrew Blake |Luisa Aring |Peng-Jui Chen |Timothy M. Fan |Young-Ah Seo

AbstractThe natural product hinokitiol mobilizes iron across lipid bilayers at low concentrations and restores hemoglobinization in iron transporter protein-deficient systems. But hinokitiol fails to similarly mobilize iron at higher concentrations, limiting its uses in chemical biology and medicine. Here we show that at higher concentrations, hinokitiol3:Fe(III) complexes form large, higher-order aggregates, leading to loss of transmembrane iron mobilization.