Pengye Du

Apr 4, 2024 | pericles.pericles-prod.literatumonline.com | Shuyu Liu |Yi Wei |Pengye Du

Ferroptosis induction is an emerging strategy for tumor therapy. Reactive oxygen species (ROS) can induce ferroptosis but are easily consumed by overexpressed glutathione (GSH) in tumor cells. Therefore, achieving a large amount of ROS production in tumor cells without being consumed is key to efficiently inducing ferroptosis. In this study, we designed a self-amplifying ferroptosis-inducing therapeutic agent, Pd@CeO2-Fe-Co-WZB117-DSPE-PEG-FA (PCDWD), for tumor therapy.

Nov 9, 2023 | onlinelibrary.wiley.com | Pengye Du |Yi Wei |Ran An

1 Introduction As modern society continues to evolve, a sharp disparity emerges between the rising demands of public health and the low efficacy and severe side effects of the traditional treatment methods (e.g., surgery, chemotherapy, and radiotherapy) used for major diseases, particularly cancer.[1-3] In light of the above, effective and robust treatment strategies and drugs must be developed to achieve optimal therapeutic effects.[4-6] Nanomaterials are considered one of the most promising...