Pere Massó

Sep 19, 2024 | biorxiv.org | Joanna Thomas |Antonios Klonizakis |Marc Alcoverro-Bertran |Pere Massó

AbstractCell-fate instructive genes tend to be regulated by large clusters of enhancers. Whether and how individual enhancers within such clusters cooperate in regulating gene expression is poorly understood. We have previously developed a computational method, SEGCOND, that identifies hubs consisting of enhancer clusters and their target genes, termed Putative Transcriptional Condensates (PTCs). Using SEGCOND, we identified PTCs in a CEBPA-induced B-cell to macrophage transdifferentiation system.