Peter Kochunov

Feb 14, 2024 | biologicalpsychiatryjournal.com | Peter Kochunov |Yizhou Ma |Si Gao |Neda Jahanshad

Genetic, pre-and-perinatal, and early-life environmental risks for severe mental disorders (SMI) alter normal cerebral development leading to formation of characteristic brain deficit patterns prior to onset of symptoms. We hypothesized that the insidious effects of these risks may increase brain similarity to adult SMI deficit patterns in prepubescent children.

Dec 7, 2023 | biologicalpsychiatryjournal.com | Noah Lewis |Peter Kochunov |Daniel H. Mathalon

AbstractSchizophrenia research reveals sex differences in incidence, symptoms, genetic risk factors, and brain function. However, a knowledge gap remains regarding sex-specific schizophrenia alterations in brain function. Schizophrenia is considered a dysconnectivity syndrome, but the dynamic integration and segregation of brain networks are poorly understood. Recent advances in resting-state fMRI allow us to study spatial dynamics, the phenomenon of brain networks spatially evolving over time.