Peter Lowe

May 5, 2023 | frontiersin.org | Dimiter S. Dimitrov |Peter Lowe |Juliette Trepreau |Taciana Manso

IntroductionCancer is the leading cause of mortality worldwide, accounting for an estimated 10 million deaths in 2020 (1). The immune system is intrinsically involved in the physiological fight against cancer, acting in the detection and elimination of the tumor. The capacity of malignant cells to express immunological checkpoint molecules on their surface is one strategy by which they avoid their destruction by the immune system.