Peter M. Kasson

2 months ago | biorxiv.org | Steinar Mannsverk |Ana Giraldo |Peter M. Kasson |Uppsala universitet

AbstractMany enveloped viruses enter cells via fusion with the endosomal membrane, raising the question whether entry through the endosomal route confers a fitness advantage over fusion directly at the plasma membrane. We found that influenza A virus fusion at the plasma membrane of A549 cells resulted in a 7.6-fold reduction in productive cell infection, compared to infection through the physiological endosomal route.