Peter Tyrer

4 weeks ago | onlinelibrary.wiley.com | Peter Tyrer |Helen Tyrer |Gin S Malhi

1 Introduction It is well established that the course of bipolar disorder may be preceded by other affective symptoms, and these may precede the first episode of hypomania or mania by many years. Apart from genetic predisposition and childhood instability of mood, there are few data examining affective symptoms and personality status in those that develop bipolar disorder.

Apr 5, 2024 | medrxiv.org | Jacob King |Helen Tyrer |Peter Tyrer

The authors have declared no competing interest. The Nottingham Study of Neurotic Disorder is supported by grants from the Mental Health Research Foundation (UK), Jessie Spencer Trust, Greater Manchester NHS Trust, Nicola Pigott Memorial Fund, and the Trent Regional Health Authority. JDK holds an Academic Clinical Fellowship funded by the National Institute for Health and Care Research (NIHR) UK. Infrastructure support for this research was provided by the NIHR Imperial Biomedical Research Centre.

Apr 12, 2023 | journals.sagepub.com | Roger Mulder |Peter Tyrer

Twenty years ago, George Vaillant, in a paper entitled ‘The Beginning of Wisdom is Never Calling a Patient a Borderline’1 noted that the diagnosis of borderline often reflects the clinician’s affective state rather than careful assessment. This was not an isolated opinion, but we argue that little has changed and that borderline in the context of personality has now become a toxic term that is hindering progress in research and treatment.