Philip Hinchliffe

Sep 30, 2024 | pubs.rsc.org | Michael Beer |Sofia Oliveira |Catherine L. Tooke |Philip Hinchliffe

Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For β-lactamases, the ability to make such predictions would contribute to understanding activity against, and development of, antibiotics and inhibitors to combat resistance.