Philip J Cowen

Aug 8, 2024 | nature.com | Michael Colwell |Hosana Tagomori |Michael Browning |Philip J Cowen

AbstractThe role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models of behaviour is challenging given the limitations of available experimental probes, notably selective serotonin reuptake inhibitors.

May 6, 2024 | nature.com | Catherine J Harmer |Philip J Cowen

AbstractLithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse effects limit its use. We previously reported that a lithium-mimetic agent, ebselen, promoted a positive emotional bias—an indicator of potential antidepressant activity in healthy participants.

Nov 4, 2023 | nature.com | Alexandra C Pike |Philip J Cowen

AbstractEating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been implicated in both the development and maintenance of eating disorders, and understanding the reasons for this inflexibility might indicate avenues for treatment development.