Philipp Schommers

Oct 13, 2024 | nature.com | Henning Gruell |Philipp Schommers

In a recent article in Science, Leon Weinberger and colleagues report on successful proof-of-concept studies of a novel strategy to control HIV-1 infection by using interfering viral particles.1 This approach radically differs from small-molecule antiretroviral drugs that can prevent disease progression and transmission by inhibiting viral replication but require life-long use.

Jul 19, 2024 | thelancet.com | Clara Lehmann |Philipp Schommers

With approximately 1·3 million new HIV type 1 (HIV-1) infections still occurring annually, there is an urgent need for an effective vaccine against HIV-1 acquisition. 1UNAIDSFact sheet 2023. Joint United Nations rogramme on HIV/AIDS. Since the first vaccine trials in the late 1980s, a variety of vaccine strategies have been tested over the past four decades. 2Haynes BF Wiehe K Borrrow P et al. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.

Nov 12, 2023 | nature.com | Philipp Schommers |Dae Sung Kim |Christoph Kreer |Henning Gruell |Elena Knops |Timo Wolf | +10 more

AbstractHuman immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers—persons with HIV-1 who naturally develop broad and potent nAbs—can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens.

Oct 4, 2023 | thelancet.com | Philipp Schommers

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