Philipp Sievers

Feb 6, 2024 | nature.com | Ling Hai |Dirk C Hoffmann |Julien Hiblot |Philipp Sievers |Miriam Ratliff |Kati J. Ernst | +6 more

AbstractTumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patient survival unresolved.

Oct 24, 2023 | nature.com | Dominik Sturm |David Capper |Felipe Andreiuolo |Christian Kölsche |Philipp Sievers |Annika K Wefers | +17 more

Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02255-1. Published online 16 March 2023. In the version of this article initially published, Arend Koch (Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany), Martin U. Schuhmann (Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany) and Ulrich W.

Mar 16, 2023 | nature.com | Dominik Sturm |David Capper |Felipe Andreiuolo |Philipp Sievers |Annika K Wefers |Ulrich Schüller | +17 more

AbstractThe large diversity of central nervous system (CNS) tumor types in children and adolescents results in disparate patient outcomes and renders accurate diagnosis challenging. In this study, we prospectively integrated DNA methylation profiling and targeted gene panel sequencing with blinded neuropathological reference diagnostics for a population-based cohort of more than 1,200 newly diagnosed pediatric patients with CNS tumors, to assess their utility in routine neuropathology.